Communication between cells in multi-cellular organisms, such as animals, humans and plants, is essential for coordinating the organismic activities of fertilisation, growth, survival and reproduction. This biochemical communication between trillions of cells in organisms can be more complex than the internet. This paper develops a CMOS circuit model of signal reception and signal transduction within a cell in response to extracellular molecular signals. A micro-sequenced model has been developed where the signal transduction steps are clocked by circadian time intervals. The model converts the chemical signalling pathway into a CMOS multi-step logical transformation cascade transducing a received signal molecule into an activated cellular protein response. This modelling technique leads to understanding cellular malfunctions (diseases) in the form of logical (electrical) faults in a circuit.
- Inderscience Publishers
- A micro-sequenced CMOS model for cell signalling pathway using ...
Development of a Cleaning Validation Method for MICRO® A07 Citric Acid Cleaner Using HPLC-CAD
AbstractA high performance liquid chromatography (HPLC) method with a Corona Charged Aerosol detector for the cleaning validation of MICRO* A07 Citric Acid Cleaner residue has been developed. The pooled average repeatability of 3 replicates at 6 concentration levels expressed as RSD was 1.3 % while the pooled average intermediate precision (intra-day repeatability in 3 days) of 3 replicates at 6 concentration levels was 2.4 %. Simulated maximum allowable carryover (MAC) was calculated by using 10 ppm of MICRO®...
Steel Fire Sprinkler Tank Inspection Case Study
These images show the steel fire sprinkler tank before any preparation work and then after preparation. The steel fire sprinkler tank was fully relined with Acothane DW. A Logistics company in Berkshire recently had an R.O.V Inspection carried out on their Fire Tank, we also provided them a sprinkler tank maintenance. The sprinkler tank inspections confirmed significant amounts of corrosion to numerous areas of the internal substrate. The overall size of the fire sprinkler tank is approximately 9.2m diameter x...
1328 Steel Fire Sprinkler Tank Case Study
These images show the steel fire sprinkler tank before any preparation work and then after preparation. The steel fire sprinkler tank was fully relined with Acothane DW.
1290 GRP Fire Sprinkler Tank Case Study
These images show the fire sprinkler tank before any preparation work and then after preparation. The fire sprinkler tank was fully relined with Acothane DW.
The challenge of safety and health in micro and small enterprises: what can be done?
A high-level policy seminar, ‘Micro and small enterprises (MSEs) in Europe: How can we make sure they are safe, healthy and productive places to work?’, was organised by EU-OSHA in Brussels in June, with representatives from the European Parliament and the European Commission, social partners and other key actors and academic experts. Discussions focused on how to ensure the health, safety and well-being of the millions of European citizens who work in MSEs, as well as the role of MSEs in the...