University of Tehran

Control of environmental health and removal of rats by α2-adrenergic antagonist and potassium channel blocker

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In stress, sympathetic system stimulation inhibits insulin release via postsynaptic alpha 2 (a2)- adrenoceptors on the pancreas beta cells, intense sympathetic stimulations interrupt the activation of beta cells in type 2 diabetes mellitus (DM). Some of the researchers believe that pretreatment with clonidine potentiated hyperglycemia. Glycogenolysis and gluconeogenesis or decrease of glucose intake by tissue cells (increase of growth hormone and epinephrine) may induce the increase of blood glucose (Hiyoshi et at., 1995). In this research, administration of yohimbine (Yo) (α2-adrenoceptor antagonist) separately or combined with glibenclamide (Gl) (adenosine triphosphate (ATP)sensitive potassium channel (KATP channel) blocker) could decrease blood glucose. By this idea, that administration of Yo and Gl may causes death of rats; oral administration of this thug may be a biologic way to defend against these animals. Archeologic studies have shown that rats were contemporain with human being in the third period of geology. In addition that rats are one of the pests of agricultural products, and produce severe damages to channels, buildings, cable wires and etc. Also data have shown that 35 diseases such as thyfus, peste, bite fever, jaundice, thyphoid, diarrhea, cholera, webbel, pig worm, trishin are transported by rats.

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