John Wiley & Sons, Ltd.

Degradation and transformation of 17α‐estradiol in water‐sediment systems under controlled aerobic and anaerobic conditions

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17α‐Estradiol is one of the principal metabolites in cattle excreta following the administration of Synovex® ONE, which contains estradiol benzoate (EB) and trenbolone acetate (TBA). As part of the environmental assessment of the use of Synovex® ONE, data were generated to characterize the fate of 17α‐estradiol in the environment. Studies were conducted to determine the degradation and transformation of 17α‐[14C]‐estradiol in two representative water‐sediment systems each under aerobic and anaerobic conditions. The same transformation products—estriol, 17β‐estradiol, and estrone—were formed, principally in the sediment phase, under both conditions in both systems. From the production of these transformation products, the DT50 (50% disappearance time) values of estrone and 17β‐estradiol were determined, along with the DT50 value of 17α‐estradiol and the total drug (17α‐estradiol + 17β‐estradiol + estrone). The results indicate that 17 α‐[14C]‐estradiol was more persistent under anaerobic conditions than under aerobic conditions, and that 17 α‐[14C]‐estradiol was less persistent than its transformation products. The DT50 values for the total system (aqueous and sediment phase), and for the total residues (17α‐estradiol, 17β‐estradiol, and estrone), were selected for use in modeling the environmental fate of EB. For aerobic degradation in the water‐sediment system, the DT50 was 31.1 days, and it was 107.8 days for the anaerobic system. This article is protected by copyright. All rights reserved

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