Detection of Low Level of Chloramphenicol in Milk and Honey with MIP SPE and LC-MS-MS

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Courtesy of Sigma-Aldrich Co., LLC

The analysis of chloramphenicol(CAP) is a challenging analysis for drug residues in food matrices.

Chloramphenicolis an antibiotic that is effective against a wide range of gram positive and gram negative bacteria in both humans and animals, however potentially fatal side effects such as aplastic anemiaare known in humans. The suspected carcinogenityof CAP is also thought to be dosage independent. Due to this toxicity in humans, CAP is completely banned in foodproducing animals within EU and USA.

Sample preparation can have a tremendous affect on the method performance due to differences in sample matrices and variability in cleanup efficiency by different sample preparation methods.

Here we compare three sample cleanup methods with regards to the chloramphenicolrecovery and cleanup. These included liquid-liquid extraction (LLE), generic polymer SPE and molecularly imprinted polymer (MIP) SPE.

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