John Wiley & Sons, Ltd.

Effects of atrazine on endocrinology and physiology in juvenile barramundi, Lates calcarifer (Bloch)

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Exposure to certain environmental contaminants such as agricultural pesticides can alter normal endocrine and reproductive parameters in wild fish populations. Recent studies have found widespread pesticide contamination across the rivers that discharge into the Great Barrier Reef lagoon. Potential impacts on native fish species exposed to known endocrine disrupting chemicals such as atrazine, simazine and diuron have not been assessed. Here, we examine the endocrine and physiological effects of short‐term, acute exposure of environmentally relevant concentrations of analytical grade atrazine in juvenile barramundi (Lates calcarifer) in a controlled laboratory experiment. Expression of hepatic vtg was not affected supporting previous studies that atrazine does not have a direct estrogenic effect via mediation of estrogen receptors. The lack of effect on brain CYP19B expression levels, combined with (i) increases in testosterone (T) and 17β estradiol (17β‐E2), and (ii) a stable T/17β E ratio, do not support the hypothesis that atrazine has an indirect estrogenic effect via modulation of aromatase expression. Gill ventilation rate, a measure of oxidative stress, did not change in contrast to other studies finding enhanced osmoregulatory disturbance and gill histopathology following atrazine exposure. To more closely reflect field conditions, we recommend that laboratory studies should focus more on examining the effects of commercial pesticide formulations which contain additional ingredients that have been found to be disruptive to endocrine function. Environ Toxicol Chem © 2014 SETAC

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