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Identification of the putative protein phosphatase gene PTC1 as a virulence-related gene using a silkworm model of candida albicans infection
Courtesy of American Society for Microbiology (ASM)
Protein phosphatases are critical for the regulation of many
cellular processes. Null mutants of 21 putative protein phosphatases of Candida
albicans were constructed by consecutive allele replacement using the URA3 and
ARG4 marker genes. A simple silkworm model of C. albicans infection was used to
screen the panel of mutants. Four null mutant (cmp1{Delta}, yvh1{Delta},
sit4{Delta}, and ptc1{Delta}) strains showed attenuated virulence in the
silkworm model relative to that of control and parental strains. Three of the
mutants, the cmp1{Delta}, yvh1{Delta}, and sit4{Delta} mutants, had previously
been identified as affecting virulence in a conventional mouse model,
indicating the validity of the silkworm model screen. Disruption of the
putative protein phosphatase gene PTC1 of C. albicans, which has 52% identity
to the Saccharomyces cerevisiae type
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