John Wiley & Sons, Ltd.

Norfloxacin drug induces reproductive toxicity and alters androgen receptor gene expression in testes and cloacal gland of male Japanese quail (coturnix japonica)

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Attempts have been made to investigate the reproductive toxicity of norfloxacin drug in Japanese quail. Male quail were administered with norfloxacin @ 20 mg/kg body weight for 14 days. Then reproductive functions and androgen receptor (AR) gene expression was examined in treated and control birds. The results of the present study indicated that fertility, cloacal gland area, sperm concentration and serum testosterone were reduced significantly (p < 0.05) on day14 in the norfloxacin treated birds. The same antibiotic resulted in up regulation (p < 0.05) of AR mRNA in the testes on 14th day of treatment. The AR mRNA expression was observed with a down regulation trend in cloacal gland of norfloxacin treated birds. Histological observations revealed that norfloxacin induces cellular atrophy in testes and change in glandular tissue in cloacal gland. The results of the present study demonstrated that norfloxacin induces testicular toxicity in Japanese quail. Environ Toxicol Chem 2013;9999:XX–XX. © 2013 SETAC

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