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Utilizing Restek reference standards for residual solvent testing
Courtesy of Restek Corporation
Restek manufactures several different residual solvent standards. These can be used for testing according to USP, the EP monograph, or other residual solvent assays, such as medical cannabis testing. The calculations involved for the use of these standards has led to questions for our technical team. This post should help provide guidance for their usage. I’ll use USPin my example calculations, but they can be applied to other methodology.
Since USP is a limit test, each residual solvent has a concentration limit based upon its potential risk to human health. For that reason, not all compounds are at the same concentration in our reference standards. As an example, Benzene has a limit of 2 ppm for the Class 1 Residual Solvents. Catalog #36279 contains benzene at 10 mg/mL. This solution would be what USP refers to as Residual Solvent Mixture RS.
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