Clinacox- Diclazuril - Anticoccidial Chemical
Diclazuril is a chemical anticoccidial, a benzeneacetonitrile derivative – synthetic compound of the triazinone family. Diclazuril is has a mode of action completely different from the existing ionophores and chemicals, available on the market. According to the anticoccidial properties of triazinones, diclazuril is active against intracellular development stages of coccidia, namely during schizogony and gametogony.
After diclurazil treatment, the first- and second-generation schizonts show extensive degenerative changes which are characterised by the loss of internal structure, the appearance of many intracytoplasmic vacuoles and incomplete merogony. Ultrastructural findings indicate that diclazuril treatment primarily affects the normal differentiation of the respective endogenous stages during parasite development. This leads to complete degeneration of schizonts and gamonts.
As an aid in the prevention of coccidiosis caused by Eimerio acervulino, E. bfunetti, E. maxima, E. mitis, E. praecox, E. necatrix and E. tenella in broiler chickens and chickens reared for laying. As an aid in the prevention of coccidiosis caused by Eimeria adenoeides, E. meleogfimitis and E. gallopavonis in turkeys for fattening.
As an aid in the prevention of coccidiosis caused by Eimeria iffesidua, Eimerio medio, Eimerio flovescens, Eimerio intestinolis, Eimerio perforons, Eimerio piriformis, Eimerio stiedoi, Eimerio mogno, E.exiguo ondE.coecicolo in rabbits for fattening and breeding. For the prevention of £ numidoe and £ grenieri in guinea fowls.
No contraindications are known under correct usage of the product.
MODE OF ADMINISTRATION
Orally, mixing into the feed.Mix 200 gram of Clinacox® 0.5% premix per ton of complete feed. This results in a final concentration of 1 g diclazuril per ton of feed (1 ppm). To ensure thorough dispersion of the product, it should be mixed with a suitable quantity (20-25 kg) of feed ingredients before incorporation in the final mix.