MSD Animal Health

Ovipast Plus

0

An opaque fluid vaccine containing formalin killed cells expressing iron regulated antigens from the epidemiologically most important serotypes of Pasteurella haemolytica and Pasteurella trehalosi in buffered physiological saline and adsorbed onto aluminium hydroxide. Thiomersal is included as a preservative. For the active immunisation of sheep as an aid in the control of pasteurellosis caused by M. haemolytica and P. trehalosi. The vaccine may be used as an aid in the control of pneumonic pasteurellosis in sheep of all ages from a minimum age of 3 weeks and in the control of systemic pasteurellosis in weaned fattening and breeding sheep.

Presentation
Per 1 ml:
5 x 108 formalin killed cells each of M. haemolytica strains A1 (S1006/77), A2 (S1126/92), A6 (S1084/81), A7 (S1078/81), A9 (S994/77) and P. trehalosi strains T3 (S1109/84), T4 (S1085/81), T10 (S1075/81), T15 (S1105/84) Alhydrogel, Thiomersal.

Uses
For active the immunisation of sheep as an aid in the control of pasteurellosis caused by M.haemolytica and P.trehalosi. The vaccine maybe used as an aid in the control of pneumonic pasteurellosis in sheep of all ages from a minimum age of 3 weeks and in the control of systemic pasteurellosis in weaned fattening and breeding sheep.
The vaccine may be used in pregnant ewes as an aid in the control of pasteurellosis in their lambs provided that the lambs receive sufficient immune colostrum during the first 1-2 days of life.

Dosage and administration
Subcutaneous injection in the lateral side of the upper neck
All sheep not previously vaccinated with Ovipast Plus must receive two injections, each of 2.0ml, separated by an interval of 4-6 weeks. Thereafter they must receive booster injections at intervals of not more than 12 months. In adult breeding ewes these yearly booster injections should be given during the pre-lambing period, 4‑6 weeks pre-lambing, as an aid in the control of pasteurellosis in their lambs.
On farms where the incidence of pasteurellosis is high, a supplementary booster vaccination with Ovipast Plus may be required 2-3 weeks prior to expected seasonal outbreaks.

Advice on correct administration
When handling sheep, stress should be avoided, particularly during the later stages of pregnancy when there is a risk of inducing metabolic disorders which may lead to abortion.
The vaccine bottle must be shaken well before use. Do not freeze.
Use sterile syringes and needles. No alcohol or other disinfectants should be used for sterilisation.
The use of an automatic vaccinator is recommended. Since the bottle is non-collapsible, a vaccinator with a vented draw-off spike or similar device must be used. The instructions supplied with such equipment should be noted and care should be taken to ensure the delivery of the full dose, particularly with the final few doses from the bottle.
No information is available on the effects of the concurrent use of this vaccine with any other. It is therefore suggested that no other vaccine should be administered within 14 days before or after vaccination with the product. If in doubt, advice should be sought from a veterinary surgeon.

Contra-indications, warnings, etc.
The vaccine contains an adjuvant and, as with most adjuvanted vaccines, immunisation may result in temporary swellings at the injection site. Typically, these swellings may be warm when compared to the surrounding area for up to 14 days after vaccination. Safety studies in lambs have shown that the swellings did not appear to inconvenience the animals or hinder neck movement.
As with all vaccines, occasional hypersensitivity reactions may occur.
The nutritional and metabolic status of pregnant ewes is extremely important at the time of vaccination. If in doubt, advice should be sought from a veterinary surgeon.

Withdrawal period
Zero days
FOR ANIMAL TREATMENT ONLY. KEEP OUT OF REACH AND SIGHT OF CHILDREN.

Pharmaceutical precautions
Store at +2oC and +8oC in the dark. Do not freeze.
Once broached use within 10 hours.
Partly used and empty packs, syringes and needles must be disposed of in accordance with the requirements for clinical waste.

Legal category
POM-VPS

Package quantities
Bottles containing 100 or 500 ml. Not all pack sizes may be marketed.

Further information
In any group of animals, a small number of individuals may fail to respond to vaccination as a result of immunological incompetence. Satisfactory immune responses will only be attained in healthy animals, thus it is important to avoid vaccination of animals which have intercurrent infection or metabolic disorder. As with most killed vaccines, significant levels of immunity cannot be expected until two weeks after the second dose vaccine in the primary vaccination course.
Evidence of efficacy of the Pasteurella component of Heptavac P Plus was generated in an experimental infection model and it is not possible to provide duration of immunity information using this system. There are reports that active immunity will last for up to one year and that passive immunity will persist for up to 4 weeks after birth in lambs from ewes vaccinated with conventional Pasteurella vaccines.

Heptavac P Plus, Ovivac P Plus and Ovipast Plus have been developed following research and development which resulted in the application of new ‘IRP’ technology for the manufacture of the pasteurella components of these vaccines. The inclusion of these IRP components should provide enhanced efficacy and cross protection e.g. protection against serotype A12, which is not included in the vaccine, has been demonstrated. Studies on the response of sheep to these vaccines show that two injections separated by an interval of 4-6 weeks are required to gain the full benefit of the ‘IRP’.

Marketing Authorisation number
Vm 01708/4401

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