BIOVET

- Macrolide Antibiotic Powder

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Tylosin is a macrolide antibiotic produced by a strain of Stfeptomyces ffadiae. It exerts its antimicrobial effect by inhibiting protein synthesis of susceptible micro-organisms. The tylosin spectrum of activity includes Gram-positive bacteria, some Gram - negative strains such as Posteufella and Mycoplasma spp. at concentrations of 16ug/ml or less. In most species peak plasma concentrations have been attained 1 to 2 hours after administration of tylosin. Compared to plasma levels clearly higher tissue concentrations have been observed. Tylosin was extensively metabolized. Most of the residues are excreted in faeces predominantly consisting of tylosin A, tylosin factor D and dihydrodesmycosin.

INDICATIONS
Pigs: Treatment and prevention of Porcine Intestinal Adenomatosis (Ileitis) associated with Lawsonia intfacellularis when the disease has been diagnosed at the group or herd level, treatment and prevention of swine dysentery caused by Bfachyspifa hyodysenteriae when the disease has been diagnosed in the herd.
Broilers and pullets: Treatment and prevention of respiratory infections caused by Mycoplasma gallisepticum and Mycoplasma synoviae, when the disease has been diagnosed in the flock. Treatment and prevention of necrotic enteritis caused by Clostridium pefffingens, when the disease has been diagnosed in the flock.


CONTRAINDICATIONS
Do not use in animals with known sensitivity to the active substance and/or to any of the excipients of the veterinary medicinal products.
Do not use in animals with known hyper sensitivity to tylosin and other macrolides. Do not use where cross-resistance to other macrolides (MLS-resistance) is suspected. Do not use in animals vaccinated with tylosin-sensitive vaccines either at the same time or within 1 week previously. Do not use in animals with hepatic disorders. Do not use in horses.

MODE OF ADMINISTRATION
Orally, well homogenized into the feed. Pharmasin® 100 mg/g premix: Administration through the feed: for the preparation of a medicated feed containing 40-200 gram tylosin perton of feed, the required amount of Pharmasin 100 mg/g should be homogenously mixed with a suitable carrier into a feed premixture so that at least 5 kg of this premixture can be added to the feed in order to obtain amedicated feed with the required concentration. As 1 kg Pharmasin® 100 mg/g premix contains 100 g tylosin activity it follows that 10 mg Pharmasin® 100 mg/g premix corresponds to 1 mg tylosin activity. Pharmasin® 250 mg/g premix: Administration through the feed: for the preparation of a medicated feed containing 40-1100 gram tylosin per ton of feed, the required amount of Pharmasin 250 mg/g Premix should be homogenously mixed with a suitable carrier into a feed premixture so that at least 5 kg of this premixture can be added to the feed in order to obtain a medicated feed with the required concentration. For the preparation of medicated feed: As 1 kg Pharmasin® 250 mg/g premix contains 250 g tylosin activity, it follows that 4 mg Pharmasin® 250mg/g premix corresponds to 1 mg tylosin activity.

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