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IGX Platform Software for Transplantation - Medical / Health Care
The immune response that occurs when an organ or tissue is transplanted (grafted) from one individual to another is referred to as a graft versus host response. This presents a major problem following transplantation as the immune system of the recipient sees the grafted tissue as foreign and proceeds to attack it.
Organ, tissue, and stem cell transplantations save thousands of lives each year. Immune rejection poses a barrier to successful transplantation and often requires transplant recipients to take lifelong immunosuppressive drugs, making them highly susceptible to opportunistic infections. Immune repertoire analysis enables the identification and tracking of clones involved in the graft versus host response occurring after transplantation. This information can aid in more accurate prognosis, tailoring treatment strategies and, eventually, the development of targeted drugs with less side-effects.