John Wiley & Sons, Ltd.

No impact of DvSnf7 RNA on honey bee (Apis mellifera L.) adults and larvae in dietary feeding tests

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The honey bee, Apis mellifera L. is the most important managed pollinator species worldwide and plays a critical role in pollination of a diverse range of economically important crops. Due to this species' importance to agriculture and its historical use as a surrogate species for pollinators to evaluate the potential adverse effects for conventional, biological and microbial pesticides, as well as for genetically engineered plants that produce pesticidal products. As part of the ecological risk assessment of MON 87411 maize, that expresses a dsRNA targeting the Snf7 ortholog (DvSnf7) in Western Corn Rootworm (WCR; Diabrotica virgifera virgifera), dietary feeding studies with honey bee larvae and adults were conducted. Based on the mode of action of the DvSnf7 RNA in WCR, studies were designed to be of sufficient duration to evaluate the potential for adverse effects on larval survival and development through emergence and adult survival through a significant portion of the adult stage. Testing was conducted at concentrations of DvSnf7 RNA that greatly exceeded environmentally relevant exposure levels based on expression levels in maize pollen. No adverse effects were observed in either larval or adult honey bees at these high exposure levels providing a large margin of safety between environmental exposure levels and no observed adverse effect levels. This article is protected by copyright. All rights reserved

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