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Background:  Lipid droplets are coated with a layer of proteins that regulate their growth and metabolism.  The major lipid droplet-associated protein in adipocytes is perilipin [1]. Mice in which the endogenous gene for perilipin is knocked out have a lean phenotype due to reduced accumulation of fat [2,3], suggesting that perilipin may have a “gate-keeper” function under basal conditions to protect the triglycerides from metabolism by lipases. Amount:  100 µL.