Ibio - Model 400 - Classical Swine Fever Vaccines

Currently available vaccines include live attenuated virus vaccines and subunit vaccines. While live attenuated virus vaccines can be efficient at triggering rapid animal immune response and protecting swine populations when combined with culling of infected pigs, current solutions do not allow the differentiation of infected from vaccinated animals (DIVA), nor are they approved for use in the U.S. Previously developed CSF virus (CSFv) subunit vaccines suffer from thermal instability and poor long-lasting protection. Therefore, the development of DIVA compatible and efficacious vaccination solutions remains a top priority to prevent the economic impacts of a CSF outbreak including supply disruptions, export restrictions and reduced food security.

In collaboration with the Institute of Infectious Animal Diseases (IIAD) within the Texas A&M University System and Kansas State University, we used the?FastPharming®?System to develop a safe and effective subunit vaccine¹ capable of differentiating infected from vaccinated animals (DIVA), a key consideration for restoration of trade status.²?Formulated in cost-effective oil-in-water emulsion adjuvants, IBIO-400 studies demonstrated that a single-dose of the adjuvanted, plant-made CSF E2 subunit vaccine provides protection in challenged pigs and is accompanied by strong virus neutralization antibody response.

Efficacy

Single-dose injection protects animals against challenge