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Taconic - Model B6.SJL -Congenic Mouse Model
Origin: The B6.SJL Congenic model was developed by Boyse et al in 1975 by intercrossing C57BL/6Boy mice to SJL/J mice. Taconic received stock from the NIAID in 1995. The mice were derived by embryo transfer into the NIAID Transgenic Mouse Repository. The mice were backcrossed by Boyse to a C57BL/6Boy inbred background to select for SJL antigen type (now referred to as Ptprca or Ly5.1). Refreshed in 2007 from NIAID stock. Further backcrossed to the C57BL/6NTac background to NE8.
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- Genetically similar to the C57BL/NTac strain except that it carries the Ptprca allele (protein-tyrosine phosphatase, receptor type c locus previously known as CD45.1, Ly5.1) and the Pep3b allele from the SJL/J strain
- The unique lymphocyte cell surface antigen produced by Ptprca makes this strain useful for immunological adoptive transfer experiments and useful as a background for transgenic and knockout models used in adoptive transfer studies
- Backcrossed to the C57BL/6NTac strain to NE8 as assessed by SNP testing.
Color: Black
Species: Mouse
Animal Diet: NIH #31M Rodent Diet