ZyMot - Fertility

The ZyMot ICSI has 5 micro-channels; each accommodating 2µl of semen. More than one micro-channel is available to accommodate multiple separations. Each channel has an inlet port for applying the semen sample and an outlet port for collecting the motile sperm. The ports are connected by a fluid-filled micro-channel in which the separating occurs. Untreated semen is added through the inlet port. After a period of time, the separated sperm are collected from the outlet port.

The ZyMot Multi (provided with 850µl and 3ml collection chambers) has an inlet port that communicates with the lower sample chamber. The sample chamber is separated from the upper collection chamber by a microporous filter. Untreated semen is added through the inlet port. After a period of time, the separated sperm are collected from the upper chamber through the outlet port.

Indications for Use:

The ZyMot ICSI Sperm Separation Device is intended for preparing motile sperm from semen for use in the treatment of infertile couples by intracytoplasmic sperm injection (ICSI) procedures.

The ZyMot Multi (850µl) Sperm Separation Device is intended for preparing motile sperm from semen for use in the treatment of infertile couples by intracytoplasmic sperm injection (ICSI), in vitro fertilization (IVF) and intrauterine insemination (IUI) procedures.

According to the World Health Organization, approximately 40–50%* of all infertility cases are due to "male factor" infertility—most often related to low concentration (oligospermia), poor motility (asthenospermia), and abnormal morphology (teratospermia). Since healthy sperm is critical to the success of ART procedures, why aren’t we doing more to protect them? (*ASRM. Quick Facts About Infertility. Available from: https://www.reproductivefacts.org/faqs/quick-facts-about-infertility/. June 12, 2018.)

To address the problem, we are commercializing two products in the USA market: ZyMot™ ICSI and ZyMot™ Multi Sperm Separation Devices.

Utilizing currently available methods, the embryologist is challenged to select the “right” sperm for use in ART procedures. Furthermore, current procedures requiring centrifugation cause irreversible damage to the sperm due to DNA fragmentation and the generation of reactive oxygen species (ROS). DxNow has developed novel devices for use in assisted reproductive technology (ART) procedures conducted by fertility clinics and OB/GYN practices. The ZyMot devices are intended for preparing motile sperm from semen for use in the treatment of infertile couples by intracytoplasmic sperm injection (ICSI), intrauterine insemination (IUI), and in vitro fertilization (IVF) procedures. These devices will be the first of their kind in the U.S. market.

The ZyMot devices simulate the cervical and uterine pathway that sperm must navigate to naturally fertilize an egg, recreating a process that has been preserved in nature for millions of years. With the goal of mimicking nature, ZyMot devices facilitate the separation and preparation of highly-motile sperm with normal morphology for use in ART procedures. Presenting a simple and straight-forward methodology, the ZyMot devices provide considerable time savings when compared to conventional methods.

• Our fertility devices eliminate the need for time-consuming sample preparation and sperm damaging centrifugation.
• The result is a simple and fast method, enabling the embryologist to consistently select sperm with higher motility, better morphology, less damaging ROS generation and lower DNA fragmentation.

• Separation of the “right” sperm and…
• requires NO sample preparation
• standardize and simplify processing
• requires NO sperm damaging centrifugation
• sperm separated in volumes required by ICSI, IUI, and IVF
• channel dimensions and incubation timing optimized for maximum separation efficiency
• select sperm with high motility, normal morphology, low ROS, low DNA fragmentation

In parallel to our activities in the human market, we are working with key opinion leaders (KOLs) in the veterinary market to validate the utility and function of these products for ART applications in animals.