Dyadic International, Inc.

Dyadic International, Inc. (OTCQX: DYAI) - We are a global biotechnology company focused on further improving and leveraging the patented and proprietary C1 expression system to help bring biologic vaccines and drugs to market faster, in greater volumes, at lower cost, and with new properties to drug developers and manufacturers to improve access and cost to patients and the healthcare system - but most importantly to save lives.

Company details

140 Intracoastal Pointe Drive, Suite 404 , Jupiter , Florida 33477-5094 USA

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Business Type:
Industry Type:
Chemical & Pharmaceuticals - Pharmaceutical
Market Focus:
Globally (various continents)

This company also provides solutions for other industrial applications.
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The rich history of Dyadic represents a microcosm of how modern biotechnology is revolutionizing science, medicine, agriculture, and engineering to improve how we feed, fuel, and heal the world.

Going forward we intend to focus on on the pharmaceutical industry which we have long believed is one of the most attractive opportunities in which to apply the C1 technology.  We believe that the C1 technology platform has the potential to be a safe and efficient expression system to help pharmaceutical and biotech companies speed up the development and lower the cost of manufacturing biologic vaccines and drugs to bring more affordable treatments to a greater number of patients, while helping to ease the burden biologic drugs are having on patients and the global healthcare systems, but most importantly saving lives. 

For Dyadic, the journey can be described as going from “Jeans to Genes”: pioneering the use of pumice stones to stonewash blue jeans in the early 1980s, shifting along with the industry to enzymes in the middle of the decade, then beginning a new journey with the discovery of a filamentous fungal strain, nicknamed C1, suitable for producing cellulase and other enzymes in the early 1990s.  Over the next two decades, Dyadic has built the knowledge, expertise, molecular tools, and technology needed to create and commercialize one of the world’s premiere gene expression systems, the C1 Technology Platform.  During C1’s development, we identified two serendipitous mutations:  the first changed the morphology of our organism, resulting in high productivity and better growth conditions;  the second created our C1 White StrainTM, which allows for the production of purer enzymes and other proteins at high productivity.

On December 31, 2015 Dyadic sold substantially all the assets of its Industrial Technology business to DuPont’s Industrial Biosciences business for US$75 million in cash. Following completion of the transaction, Dyadic intends to focus exclusively on its biopharmaceutical business.     DuPont has granted back to Dyadic co-exclusive rights to the C1 technology for use in human and animal pharmaceutical applications, with exclusive ability to enter into sub-license agreements in that field.

The combination of a portion of the proceeds from the US$75 million DuPont transaction and additional industry and government funding that will be sought are expected to provide Dyadic with the ability to focus on and accelerate the further development and optimization of the C1 technology in the area of biopharmaceuticals.  In addition, the unique attributes of C1 may create attractive licensing opportunities through operational efficiencies and reduced requirements for licensee capital expenditures.

With the speed of advancements in synthetic genomics and biotechnology, which some experts say is happening faster than Moore’s Law, it is vital to bridge the gap between high yield, low cost, large scale industrial biotechnology, and low yield, high cost, small scale biopharmaceuticals.  We believe C1 can help bridge this gap and we are now starting to introduce this breakthrough technology to the biopharmaceutical industry.

Dyadic today is still led by its pioneering founder, and its management team has a unique mix of established industry veterans.

Dyadic is seeking partnerships to sub-license or partner its C1 platform technology in the vaccine, antibody and biosimilar industries


Dyadic uses its proprietary C1 platform technology to discover and develop novel genes and other biological products from eukaryotic organisms found in the full spectrum of the earth’s biodiversity. Once useful genes are isolated, Dyadic uses its integrated platform to manufacture specific proteins, doing so more rapidly and efficiently — and with a much higher rate of success than existing gene discovery systems.


Dyadic leverages its proprietary technology platform to discover novel genes and biological products for use by its strategic partners, and to further its own R&D efforts.

Dyadic seeks strategic alliances with major leaders in the agricultural, bioenergy, industrial enzyme, chemical and biopharmaceutical industries that have in-house genomic capabilities. Dyadic will also collaborate with companies whose genomic capabilities are limited, discovering and expressing biological materials for these strategic partners.

In addition, Dyadic, using these proprietary systems, will continue to commercialize enzymes for use in targeted markets, including the animal nutrition, detergent, ethanol, pulp and paper, biopharmaceutical, starch and textile industries.

Dyadic expects to generate revenue from its product sales, revenue generated from research and development services and funding as well as revenue generated from licensing and other strategic collaborations in the form of milestone and royalty payments.