Heat shock protein (HSP90) belongs to a family of molecular chaperones which are rapid and abundantly induced by stresses. HSP90 plays a crucial role in stabilizing denatured proteins that have become misfolded or unfolded because of cellular stress and by aiding in their re-folding. So far, many of the proteins identified as HSP90 clients are key components of the oncogenic phenotype involved in controlling many of the hallmarks of cancer.
