- Luteinizing Hormone - Releasing Hormone Analogue for Gamete Maturation

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The use of hormones to induce gamete maturation (ovulation and spermiation) and spawning in fishes is crucial to the success of many aquaculture and wild stock fisheries programs.  Gamete maturation can be induced by a variety of hormones.  However, because of its high biological activity and low species specificity, synthetic Luteinizing Hormone-Releasing Hormone analog (LHRHa) is now a candidate for approval for the above-described use by the US FDA under INAD #8061.

Luteinizing Hormone - Releasing Hormone analogue (des-Gly10, [D-Ala6] LH-RH Ethylamide) or LHRHa is a peptide that is similar in structure to native luteinizing hormone-releasing hormones (LHRH).  LHRHa has both biological activity and low species specificity in fish, making it appropriate for use on a variety of fish species

LHRHa is sold as a powder and typically dissolved in sterile saline and administered to fish as an intraperitoneal (IP) or intramuscular (IM) injection

If the intended LHRHa use is to treat food fish, or fish for release into the wild, then it must be used according to the FDA's guidelines for Investigational New Animal Drug Application - INAD #8061.  More information including INAD application forms, study protocols, study summaries, etc. can be obtained from the U.S. Fish & Wildlife Service's office of Aquatic Animal Drug Approval Partnership Program (AADAP).  The AADAP office has streamlined the INAD process and the staff there are very helpful.  If you are interested in using LHRHa to treat food fish, or fish for release, please contact the AADAP office.

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